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ChemicalBook CAS DataBase List 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylic acid
253315-24-1

2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylic acid synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: ethanol / 2 h / Reflux; Inert atmosphere
2: lithium hydroxide monohydrate / methanol; water / Inert atmosphere

References:

Li, Guoliang;He, Yundong;Zhou, Wenbo;Wang, Peng;Zhang, Yong;Tong, Weiguang;Wu, Haigang;Liu, Mingyao;Ye, Xiyun;Chen, Yihua [Heterocycles,2014,vol. 89,# 2,p. 453 - 464]