2-(4-CHLOROPHENYL)-2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]ACETONITRILE synthesis
- Product Name:2-(4-CHLOROPHENYL)-2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]ACETONITRILE
- CAS Number:213993-80-7
- Molecular formula:C14H7Cl2F3N2
- Molecular Weight:331.12
69045-84-7
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Yield:213993-80-7 42%
Reaction Conditions:
Stage #1: p-chlorobenzyl cyanidewith sodium hydride in N,N-dimethyl-formamide; for 0.25 h;NaH in DMF was mixed with DMF-soln. of CN-compd. within 20 min;Stirring;
Stage #2: 2,3-dichloro-5-trifluoromethylpyridine for 0.333333 h;CF3-compd. was added dropwise within 20 min;
References:
US6337305,2002,B1 Location in patent:Example 1