ChemicalBook CAS DataBase List tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate synthesis

4synthesis methods

Product Name:tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate
CAS Number:201162-53-0
Molecular formula:C11H20N2O2
Molecular Weight:212.29

201162-52-9 Synthesis

tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate

201162-52-9
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tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate

201162-53-0
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$18.00/100mg

Yield:201162-53-0 100%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol; under 760.051 Torr; for 18 h;

Steps:

23.B 3,8-Diaza-bicyclo[3.2.1]octane-3-carboxylic Acid tert-butyl Ester

Example 23B 3,8-Diaza-bicyclo[3.2.1]octane-3-carboxylic Acid tert-butyl Ester A solution of the product of Example 23A (0.62 g. 0.12 mmol) in EtOH (10 mL) was stirred with Pd/C (Aldrich, 60 mg, 10 wt %) under 1 atmosphere of H₂ (balloon) for 18 h. The mixture was filtered, concentrated and purified by column chromatography (SiO₂, 1% NH₄OH: 9% CH₃OH: 90% CH₂Cl₂) to provide the title compound (0.44 g, 100% yield). MS (DCl/NH₃) m/z 213 (M+H)⁺.

References:

US2005/101602,2005,A1 Location in patent:Page/Page column 35