2-(TRIFLUOROMETHYL)BENZYLAMINE synthesis
- Product Name:2-(TRIFLUOROMETHYL)BENZYLAMINE
- CAS Number:3048-01-9
- Molecular formula:C8H8F3N
- Molecular Weight:175.15
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Yield:-
Reaction Conditions:
Stage #1: 1-(azidomethyl)-2-(trifluoromethyl)benzenewith hydrogenchloride;tin(ll) chloride in water at 80; for 2 h;
Stage #2: with sodium hydrogencarbonate in water;
Steps:
4.2
Step 2 -Preparation of 1-[2-(trifluoromethyl)phenyl]methanamine To a solution of step-1 intermediate (0.200 g, 0.993 mmol) in conc. HCl tin (II)chloride (0.673 g, 2.98 mmol) was added. The reaction mixture was stirred at 80° C. for 2 h. The reaction mixture quenched in water, neutralized with sodium bicarbonate and extracted with mixture of (1-1.5%) methanol: DCM. The organic layer was separated, dried over anhydrous sodium sulphate and concentrated to afford 0.150 g of the desired product. 1HNMR (DMSO-d6): δ 7.43 (d, J=7.2 Hz, 2H), 7.64-7.66 (m, 3H), 7.78 (m, 1H).
References:
US2012/108583,2012,A1 Location in patent:Page/Page column 23
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![Benzenemethanamine, 2-(trifluoromethyl)-N-[[2-(trifluoromethyl)phenyl]methylene]-](/CAS/20210305/GIF/1280540-91-1.gif)