2-(thiophen-3-yl)isonicotinaldehyde synthesis
- Product Name:2-(thiophen-3-yl)isonicotinaldehyde
- CAS Number:1403932-10-4
- Molecular formula:C10H7NOS
- Molecular Weight:189.23
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1403932-10-4
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Yield:1403932-10-4 87.4%
Reaction Conditions:
Stage #1: Thien-3-ylboronic acid;2-bromopyridine-4-carboxaldehydewith sodium carbonate;tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran at 85;
Stage #2: with sodium hydrogencarbonate in water;
Steps:
1
2-(thiophen-3-yl)isonicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromoisonicotinaldehyde and thiophen-3-ylboronic acid (89 mg, 101.8 mg theoretical, 87.4%). LC-MS m/z 190.2 (M+1).
References:
US2012/270892,2012,A1 Location in patent:Page/Page column 80