2-(Pyridin-2-yl)propan-1-ol synthesis

7synthesis methods

Product Name:2-(Pyridin-2-yl)propan-1-ol
CAS Number:68888-19-7
Molecular formula:C8H11NO
Molecular Weight:137.18

21883-27-2
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68888-19-7
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Yield:68888-19-7 84%

Reaction Conditions:

with lithium aluminium hydride in tetrahydrofuran at 0 - 20; for 1.5 h;

Steps:

3 Step 3:

Step 3: To a solution of methyl ester OOOOOO (43.0 g, 260.3 mmol, 1.0 equiv.) in THF (1500 mL, 0.1M) at 0° C. was added lithium aluminum hydride (312 mL, 312.4 mmol, 1.2 equiv., solution in THF) dropwise. The reaction was allowed to warm gradually to 0° C. for 30 minutes and then to room temperature for 1 hour or until the reaction was determined to be complete by LCMS or TLC. The reaction was carefully quenched with water, sodium hydroxide and water. After stirring the mixture for 30 minutes, the white precipitate was filtered off and the solvent was removed in vacuo. The reaction was then extracted with diethyl ether and the combined organic fractions were washed with water, brine, dried over magnesium sulfate, filtered, and concentrated in vacuo. The resulting alcohol (PPPPPP, 30.0 g, 219.0 mmol, 84%) was advanced without purification.

References:

US2015/329528,2015,A1 Location in patent:Paragraph 0099; 0102

67-56-1 Synthesis