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ChemicalBook CAS DataBase List 2-Phenylbutyric acid
90-27-7

2-Phenylbutyric acid synthesis

10synthesis methods
-

Yield:90-27-7 81%

Reaction Conditions:

Stage #1:1-phenylpropene with 9-borabicyclo[3.3.1]nonane dimer in 2-methyltetrahydrofuran at 70; for 24 h;Sealed tube;
Stage #2:carbon dioxide with cesium fluoride;sodium t-butanolate;1,3-bis[2,6-diisopropylphenyl]imidazolium chloride in 2-methyltetrahydrofuran at 120; for 24 h;Sealed tube;regioselective reaction;

References:

Gevorgyan, Ashot;Hopmann, Kathrin H.;Bayer, Annette [ChemSusChem,2020,vol. 13,# 8,p. 2080 - 2088]

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