ChemicalBook CAS DataBase List 2-Oxa-8-azaspiro[4.5]decane

2-Oxa-8-azaspiro[4.5]decane synthesis

10synthesis methods

Product Name:2-Oxa-8-azaspiro[4.5]decane
CAS Number:176-69-2
Molecular formula:C8H15NO
Molecular Weight:141.21

374794-96-4 Synthesis

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate

374794-96-4
51 suppliers
$35.00/100mg

176-69-2
60 suppliers
$98.00/50mg

Yield: 88%

Reaction Conditions:

with hydrogenchloride in methanol at 0 - 20; for 24 h;

Steps:

44 DESCRIPTION 44; 2-Oxa-8-azaspiro[4.5]decane
Methanolic hydrogen chloride (3M, 3 mL) was added to a stirred, cooled (020 C.) solution of 1,1-dimethylethyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate (Description 43, 150 mg, 0.62 mmol) in methanol and the mixture was stirred at room temperature for 24 hours. The solvent was evaporated under reduced pressure and the residue was dissolved in methanol and passed through Amberlyst 26 ion exchange resin, eluting with methanol. The solvent was evaporated under reduced pressure and the residue was dissolved in dichloromethane, dried (Na2SO4) and the solvent was evaporated under reduced pressure to give the title compound (77 mg, 88%). m/z (ES+) 142 (M+1).

References:

Pineiro, Jose Luis Castro;Dinnell, Kevin;Elliott, Jason Matthew;Hollingworth, Gregory John;Shaw, Duncan Edward;Swain, Christopher John;Yang, Lihu US2003/225059, 2003, A1 Location in patent:Page 27