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ChemicalBook CAS DataBase List 2-Nitro-4-(trifluoromethoxy)aniline
2267-23-4

2-Nitro-4-(trifluoromethoxy)aniline synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: acetic acid / 0.25 h / Heating
2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min
3: conc. sulfuric acid / 0.25 h / 100 °C

References:

Monge, Antonio;Palop, Juan A.;Cerain, Adela Lopez de;Senador, Virginia;Martinez-Crespo, Francisko J.;et al. [Journal of Medicinal Chemistry,1995,vol. 38,# 10,p. 1786 - 1792]

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