2-methylpiperidine, (±) synthesis

15synthesis methods

Product Name:2-methylpiperidine, (±)
CAS Number:3000-79-1
Molecular formula:
Molecular Weight:0

13603-27-5
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3000-79-1
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Yield:3000-79-1 86%

Reaction Conditions:

with zirconium(IV) oxide at 350;Inert atmosphere;

Steps:

5 Example 5.

0.3 g of silicon oxide (Q-6) was filled in a quartz reaction tube,1.60 cm 3 / h of 6-amino-2-hexanol,Nitrogen gas was flowed at 20 cm 3 / min, and the reaction was carried out at 350 ° C.As a result of analyzing the product by gas chromatography,The conversion of 6-amino-2-hexanol was 75%The selectivity of 1-methyl-piperidine was 88%The reaction yield of 1-methyl-piperidine was 66%.; Except for replacing silicon oxide (Q-6) in Example 4 with zirconium oxide (tetragonal)The gas phase reaction was carried out according to the method described in Example 4.As a result of analyzing the product by gas chromatography,The conversion of 6-amino-2-hexanol is 95%The selectivity of 1-methyl-piperidine is 90%The reaction yield of 1-methyl-piperidine was 86%

References:

JP2018/123080,2018,A Location in patent:Paragraph 0030; 0031