ChemicalBook CAS DataBase List 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE

2-METHOXY-4,6-DIMETHYLNICOTINONITRILE synthesis

11synthesis methods

Product Name:2-METHOXY-4,6-DIMETHYLNICOTINONITRILE
CAS Number:65515-39-1
Molecular formula:C9H10N2O
Molecular Weight:162.19

14237-71-9
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124-41-4 Synthesis

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65515-39-1
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Yield:65515-39-1 100%

Reaction Conditions:

in methanol; for 1 h;

Steps:

16 Preparation 162-methoxy-4,6-dimethyl-pyridine-3 -carbonitrile

Add a solution of NaOCH3 in MeOH (30 mass%, 175 mL, 940 mmol) drop wise to a solution of 2-chloro-4,6-dimethyl-pyridine-3 -carbonitrile (75 g, 441.1 mmol) inMeOH (450 mL) in a water bath followed by another drop wise addition of NaOCH3 in MeOH (25 mass%, 250 mL, 1090 mmol). Stir the resulting mixture for 1 hr, pour in ice cold water, stir for 30 mm, and filter the resulting solid. Wash filter cake with hexane and dry in a vacuum oven overnight. Extract the aqueous filtrate with DCM, dry the organic phase over Mg504, filter and concentrate in vacuo. Combine the filtered solid and theevaporated residue to afford title compound as a solid (71.8 g, quantitative yield). ES/MS (mlz): 163 (M+H).

References:

WO2017/35060,2017,A1 Location in patent:Page/Page column 48; 49

67-56-1 Synthesis