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ChemicalBook CAS DataBase List 2-Isopropylphenol
88-69-7

2-Isopropylphenol synthesis

12synthesis methods
-

Yield:88-69-7 90%

Reaction Conditions:

with iron(III) oxide;oxygen in tetrahydrofuranIrradiation;

Steps:

General procedure for the preparation of phenols from arylboronic acids:
General procedure: In atypical procedure, a flask containing phenylboronic acid (100 mg, 0.82 mmol) was taken and to it were added 10 mol % of iron(III) oxide photocatalyst(13.1 mg) and tetrahydrofuran (2 ml). The reaction mixture was kept for stirring under diffused sunlight in ordinary open flask until the starting material is consumed on TLC. Quenched with water after completion and the catalyst was filtered off, the filtrate was concentrated in vacuo. The crudeproduct was purified on silica (100-200 mesh) column chromatography (15%ethylacetate/hexane) to offer 73.2 mg (in 95% yield) of pure crystalline phenol.

References:

Sawant, Sanghapal D.;Hudwekar, Abhinandan D.;Aravinda Kumar;Venkateswarlu, Vunnam;Singh, Parvinder Pal;Vishwakarma, Ram A. [Tetrahedron Letters,2014,vol. 55,# 4,p. 811 - 814]

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