ChemicalBook CAS DataBase List 2-Fluorobiphenyl

2-Fluorobiphenyl synthesis

14synthesis methods

Product Name:2-Fluorobiphenyl
CAS Number:321-60-8
Molecular formula:C12H9F
Molecular Weight:172.2

348-52-7 Synthesis

348-52-7
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$6.00/5g

98-80-6 Synthesis

98-80-6
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$5.00/5g

321-60-8
279 suppliers
$9.00/1g

Yield:321-60-8 97%

Reaction Conditions:

with C₂₈H₄₀Br₄N₄Pd₂;potassium carbonate in water;acetone at 20; for 1 h;Suzuki Coupling;

Steps:

4.3 General procedure of Suzuki reaction
General procedure: A mixture of aryl halide (1 mmol), arylboronic acid (1.2 mmol), catalyst A (1 mol %, 0.0096 g), K₂CO₃ (2 mmol), and (1:1) acetone/water mixed solvent (3 mL) were taken in 25 mL round bottom flask and the mixture was stirred at room temperature (40 °C for heteroaryl halides) until the completion of reaction (required time given in Tables 3-5). The reaction mixture was then diluted with water (20 mL) and extracted three times with dichloromethane (3×10 mL). The combined organic layer was washed with brine (20 mL) and dried over anhydrous Na₂SO₄. After that it was concentrated under reduced pressure and the crude product was purified by column chromatography on silica gel (60-120 mesh) using petroleum ether (60-80 °C) and ethyl acetate were as the eluent.

References:

Gupta, Sumanta;Basu, Basudeb;Das, Sajal [Tetrahedron,2013,vol. 69,# 1,p. 122 - 128]

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