2'-Deoxycytidine hydrochloride synthesis
1synthesis methods
- Product Name:2'-Deoxycytidine hydrochloride
- CAS Number:3992-42-5
- Molecular formula:C9H14ClN3O4
- Molecular Weight:263.68
Yield: 78%
Reaction Conditions:
Stage #1:p-toluenesulfonyl chloride;3',5'-O-bis(4-chlorobenzoyl)-2'-deoxy-β-D-cytidine with sodium hydroxide in methanol at 40; for 4.5 h;Large scale;
Stage #2: with hydrogenchloride in methanolLarge scale;
References:
Komatsu, Hironori;Morizane, Kunihiko;Kohno, Toshiyuki;Tanikawa, Hiroharu [Organic Process Research and Development,2004,vol. 8,# 4,p. 564 - 567]