2-CYANO-N-(3,5-DICHLORO-PHENYL)-ACETAMIDE synthesis
1synthesis methods
- Product Name:2-CYANO-N-(3,5-DICHLORO-PHENYL)-ACETAMIDE
- CAS Number:63035-00-7
- Molecular formula:C9H6Cl2N2O
- Molecular Weight:229.06
Yield:63035-00-7 52%
Reaction Conditions:
Stage #1: cyanoacetic acidwith phosphorus pentachloride in dichloromethane at 40; for 0.5 h;
Stage #2: 3,5-Dichloroaniline in dichloromethane at 40;
References:
Liang, Xuewu;Sun, Chenxia;Li, Chunpu;Yu, Haolan;Wei, Xiaohui;Liu, Xuyi;Bao, Wei;Shi, Yuqiang;Sun, Xiaochen;Khamrakulov, Mirzadavlat;Yang, Chenghua;Liu, Hong [Journal of Medicinal Chemistry,2021,vol. 64,# 13,p. 9217 - 9237]