2-Chloronicotinamide synthesis
- Product Name:2-Chloronicotinamide
- CAS Number:10366-35-5
- Molecular formula:C6H5ClN2O
- Molecular Weight:156.57
6602-54-6
495 suppliers
$6.00/10g
10366-35-5
198 suppliers
$9.00/10g
Yield:10366-35-5 98%
Reaction Conditions:
Stage #1:2-chloro-3-pyridinecarbonitrile with sulfuric acid at 90; for 2 h;
Stage #2: with ammonium hydroxide for 1 h;Cooling with ice;
Steps:
1 Preparation of 2-Chloronicotinamide (Compound B)
To 1000ml three-necked flask was added concentrated sulfuric acid 400ml, 2-chloronicotinonitrile (138g, 1mol), completely dissolved, warmingTo 90 ° C, stirred for 2 hours,The reaction mixture was poured into a mixture of 1000 ml of ammonia water and 1 kg of ice and stirred for 1 hour. After filtration, the crude solid was obtained by filtration. The crude product was added to 1000 ml of ethyl acetate, stirred for 1 hour and separated by filtration to obtain a white solid. The white solid was further dried by blowing at 50 ° C to afford 153 g of the intermediate 2-chloronicotinamide as a white solid in 98% yield.
References:
Beijing Ha Sanlian Science And Technology Co., Ltd.;Harbin Sanlian Pharmaceutical Co., Ltd.;Liu Jinai;Li Yuanzhen;Ning Ruibo;Wang Mingxin CN105367571, 2017, B Location in patent:Paragraph 0014; 0037; 0038
49609-84-9
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10366-35-5
198 suppliers
$9.00/10g
1452-94-4
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10366-35-5
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2942-59-8
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10366-35-5
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36404-88-3
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6602-54-6
495 suppliers
$6.00/10g
10366-35-5
198 suppliers
$9.00/10g