2-Chloro-N-phenylacetamide synthesis
15synthesis methods
- Product Name:2-Chloro-N-phenylacetamide
- CAS Number:587-65-5
- Molecular formula:C8H8ClNO
- Molecular Weight:169.61
Yield: 81%
Reaction Conditions:
with [2,2]bipyridinyl;boron trifluoride diethyl etherate;palladium diacetate;Trimethylacetic acid in toluene at 120; for 24 h;
Steps:
20
The preparation method was as follows. 1.3 mg of palladium acetate, 0.9 mg of 2,2'-bipyridine, 18.6 mg of aniline, 243.1 mg of 2-chloro-N, N-dimethylacetamide, 40.9 mg Pivalic acid, 42.6 mg of boron trifluoride ether complex and 2.0 mL of toluene.Placed in an oil bath at 120 ° C for 24 hours.Conventional treatment yielded 27.5 mg of pure product in 81% yield.
References:
Shanghai Jiao Tong University;Guo Xunxiang;Gu Dawei CN104961644, 2017, B Location in patent:Paragraph 0145-0148
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