(2-CHLORO-5-NITROPHENYL)(MORPHOLINO)METHANONE synthesis
- Product Name:(2-CHLORO-5-NITROPHENYL)(MORPHOLINO)METHANONE
- CAS Number:142439-65-4
- Molecular formula:C11H11ClN2O4
- Molecular Weight:270.67
Yield:142439-65-4 80%
Reaction Conditions:
in acetone at 20; for 0.5 h;Sealed tube;Inert atmosphere;
Steps:
3.a.1.a PREPARATION OF NITRO-SUBSTITUTED PHENYL-CARBONYL AMINE (Bl- B9)
General procedure: To a solution of substituted nitro benzoyl chloride A1-A9 (4.5 mmol) in acetone (5.0 mL) was added a solution of appropriate amine (0.992 mg, 2.5 eq.) in acetone (1.0 mL) at RT. The mixture was stirred in a sealed vial for 0.5 h. Upon complete consumption of starting material, the reaction mixture was concentrated in vacuo to afford a yellow oil. The oil was triturated in (1: 1) Et20/hexanes or chromatographed to liberate a pale yellow solid B1-B9.
References:
WO2019/126567,2019,A1 Location in patent:Paragraph 00332; 00335; 00336
