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96440-05-0

2-CHLORO-3-ETHYL PYRIDINE synthesis

2synthesis methods
-

Yield:96440-05-0 88%

Reaction Conditions:

with hydrogenchloride;thionyl chloride;nitric acid in water at 0 - 5;

Steps:

2 Example 2

61g of 2-amino-3-ethylpyridine was added to 100g of concentrated hydrochloric acid,Then, hydrogen chloride was added to saturation. 179 g of thionyl chloride and 75 g of 63% nitric acid were added at a temperature of 0 to 5° C. The reaction was stirred and the reaction was terminated, giving 62.9 g of 2-chloro-3-ethylpyridine (88%). %, purity 99%).

References:

CN105061300,2018,B Location in patent:Paragraph 0018; 0019