ChemicalBook CAS DataBase List 2-BROMO-6-METHYL-4-NITROANILINE

2-BROMO-6-METHYL-4-NITROANILINE synthesis

3synthesis methods

Product Name:2-BROMO-6-METHYL-4-NITROANILINE
CAS Number:102170-56-9
Molecular formula:C7H7BrN2O2
Molecular Weight:231.05

99-52-5 Synthesis

99-52-5
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102170-56-9
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Yield:102170-56-9 99%

Reaction Conditions:

with bromine;acetic acid at 20; for 1.16667 h;

Steps:

A Step A: 2-Bromo-6-rnethyl-4-nitroaniiine.

To a suspension of 2-methyl-4-nitroaniline (10.0 g, 65.7mrnol) in glacial acetic acid (100 rnL) at 20 °C was added bromine (3.4 mL, 66 rnmoi) dropwiseover 40 mm. The mixture was stirred at 20 °C for another 30 mm. Then water (100 rnL) was added, and the resulting precipitate was collected by filtration and dried in vaeuo at 80 °C for 6 h to yield the title compound (14.1 g, 99%) as a yellow solid. MS (ESi): mass calcd. for C7HBrN2O2 23 0.0, m/z found 231 [M+Hft. ‘H NMR (300 MHz, DMSO-d6) ? 8.13 (d, J = 2.2 Hz, iH), 7.89 (d, J= 1.5 Hz, IH), 6.48 (s, 2H), 2.22 (s, 3H).

References:

WO2016/176460,2016,A1 Location in patent:Page/Page column 97