ChemicalBook CAS DataBase List 2-Bromo-6-fluorobenzoic acid

2-Bromo-6-fluorobenzoic acid synthesis

11synthesis methods

Product Name:2-Bromo-6-fluorobenzoic acid
CAS Number:2252-37-1
Molecular formula:C7H4BrFO2
Molecular Weight:219.01

The synthesis and preparation method of the 2-bromo-6-fluorobenzoic acid comprises the following steps: by using o-fluorobenzonitrile as an initial raw material, carrying out nitrification, nitroreduction, bromization, diazo-deamination and hydrolysis to synthesize the 2-bromo-6-fluorobenzoic acid.

79544-27-7 Synthesis

79544-27-7
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$10.00/5g

2252-37-1
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$9.00/1g

Yield:2252-37-1 95%

Reaction Conditions:

with potassium hydroxide for 48 h;Reflux;

Steps:

3 2-bromo-6-fluorobenzoic acid, 11
A solution 2-bromo-6-fluorobenzonitrile 10 in KOH 1M (25mL) was stirred to reflux for 2 day. The reaction was cooled to room temperature and the HCl concentrate was added to pH=2-3. The aqueous solution was extracted with ethyl acetate (3 times). The organic layer was separated, dried and evaporated to obtain the desired product (126mg, yield: 95%>). C₇H₄BrF0₂, MS-ESI: [M-H]^~=218m/z. 1H-NMR: (CDCI₃, 400MHz) δ 7.14 (t, IH, Jo=8.4Hz, H-4), 7.29-7.35 (m, IH, H-3), 7.45 (d, IH, H-5).

References:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;ARANCIO, Ottavio;DENG, Shixian;LANDRY, Donald, W.;FIORITO, Jole;PURGATORIO, Rosa WO2015/153410, 2015, A1 Location in patent:Paragraph 00231-00235

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1073-06-9 Synthesis