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ChemicalBook CAS DataBase List 2-Bromo-5-methylpyrazine
98006-90-7

2-Bromo-5-methylpyrazine synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: ammonia / methanol / 4 h / 0 - 5 °C
2.1: potassium hydroxide; bromine / water / 0 - 90 °C
3.1: hydrogen bromide / water / 25 - 30 °C
3.2: 1 h / -50 °C
3.3: 1.5 h / -50 °C

References:

KomReddy, Venugopal;Rillema, D. Paul;Nguyen, Huy;Kadel, Lava [Journal of Heterocyclic Chemistry,2019,vol. 56,# 3,p. 972 - 979]

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