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ChemicalBook CAS DataBase List 2-Bromo-4-fluoroaniline
1003-98-1

2-Bromo-4-fluoroaniline synthesis

6synthesis methods
-

Yield:1003-98-1 95%

Reaction Conditions:

with N-Bromosuccinimide in N,N-dimethyl-formamide;

Steps:

3.1.1-5

Add 200 mL distilled DMF and 4-fluoroaniline (8.64 mL, 58.13 mmol) to a two neck flask. Slowly dropwise N-Bromosuccinimide (11.4 g, 63.95 mmol) dissolved in DMF. When the reaction is complete, extract with CH2Cl2. Purification by column separation (EA: Hx = 1: 4) (yield: 95%)

References:

KR2018/50795,2018,A Location in patent:Paragraph 0134; 0135; 0152-0154

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