2-BROMO-4-CHLOROPHENYL ACETATE synthesis
- Product Name:2-BROMO-4-CHLOROPHENYL ACETATE
- CAS Number:98434-18-5
- Molecular formula:C8H6BrClO2
- Molecular Weight:249.49
Yield:98434-18-5 96%
Reaction Conditions:
with triethylamine in dichloromethane at 0; for 3 h;
Steps:
22 Intermediate 94: 2-bromo-4-chlorophenyl acetate
To a solution of 2-bromo-4-chlorophenol (20 g, 96 mmol) in Dichloromethane (200 mL) was added acetyl chloride (1 1 .35 g, 145 mmol) and triethylamine (29.3 g, 289 mmol). The mixture was stirred at 0 °C for 3 h. Water was then added and the mixture was extracted with ethyl acetate. The organic layer was dried over Na2S04, filtered and purified by chromatography on silica gel (hexane/EtOAc = 5/1 ) to give the desire product 2-bromo-4-chlorophenyl acetate (23 g, 92 mmol, 96 % yield) as a yellow solid. 1 H NMR (400 MHz, CDCI3) δ 7.60 (d, J = 2.5Hz, 1 H), 7.29 (dd, J = 2.5, 8.5Hz, 1 H), 7.05 (d, J = 8.5Hz, 1 H), 2.34 (s, 1 H)ppm
References:
WO2019/63748,2019,A1 Location in patent:Page/Page column 277