ChemicalBook CAS DataBase List 2-Benzoylpyridine

2-Benzoylpyridine synthesis

14synthesis methods

Product Name:2-Benzoylpyridine
CAS Number:91-02-1
Molecular formula:C12H9NO
Molecular Weight:183.21

110-86-1 Synthesis

110-86-1
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$9.00/5g

100-51-6 Synthesis

100-51-6
1391 suppliers
$5.00/100g

91-02-1
222 suppliers
$6.00/5g

Yield:91-02-1 85%

Reaction Conditions:

with dipotassium peroxodisulfate in water at 120; for 18 h;Green chemistry;regioselective reaction;

Steps:

General procedure for 2-acylation of pyridines
General procedure: A 10 mL microvawe vial was charged with pyridine derivatives (1 equiv, 1 mmol), alcohol derivatives (2 equiv, 2 mmol), K₂S₂O₈ (2 mmol, 540 mg) and water (H₂O, 2 mL). The vial was then sealed and immersed in an oil bath, which was preheated at 120°C, for 18 h. After this time the reaction mixture was then cooled to room temperature and diluted with water (3 mL) and the aqueous phase was extracted with dichloromethane (2 x 5 mL). The organic extracts were dried over sodium sulfate and filtered. Concentration of the solution by rotary evaporation under reduced pressure gave a residue which was purified by using column chromatography (n-hexane/EtOAc, 4/1) to yield the desired products.

References:

Kianmehr, Ebrahim;Pakbaznia, Azin;Faghih, Nasser;Foroumadi, Alireza [Tetrahedron,2017,vol. 73,# 11,p. 1407 - 1412]

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