ChemicalBook CAS DataBase List 2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE

2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE synthesis

7synthesis methods

Product Name:2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE
CAS Number:22312-61-4
Molecular formula:C13H11ClN2O
Molecular Weight:246.69

73544-84-0 Synthesis

73544-84-0
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22312-61-4
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Yield:22312-61-4 94.5%

Reaction Conditions:

with palladium on activated charcoal;ammonium formate in ethanol at 80; for 3 h;

Steps:

1.2 second step, the preparation of 2-amino-N-phenylbenzamide

2.76 g (0.01 mol) of 2-nitro-N-phenylbenzamide was weighed into a 100 mL reaction flask.Add 50 mL of ethanol and stir to dissolve, add 1.91 g (0.03 mol) of ammonium formate,0.44 g of palladium on carbon, heated at 80 ° C, and the reflux tube was refluxed. After 3 hours, the reaction was detected by TLC.The raw material point disappeared completely and the reaction was terminated. The reaction solution is filtered to remove palladium carbon.The filter cake was washed twice with ethanol, and the reaction mixture was evaporated.Add 3mL of 70% ethanol aqueous solution to recrystallize, heat and dissolve, and then naturally cool.A white solid precipitated and was filtered and dried to give a white solid, 1.62 g.The yield was 94.5%.

References:

CN110041272,2019,A Location in patent:Paragraph 0069; 0074-0076

118-48-9 Synthesis