2-Acetamino-4-aminopyridine synthesis

8synthesis methods

Product Name:2-Acetamino-4-aminopyridine
CAS Number:75279-39-9
Molecular formula:C7H9N3O
Molecular Weight:151.17

Acetamide, N-(4-nitro-2-pyridinyl)-, oxide (9CI)

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Yield:75279-39-9 92.2%

Reaction Conditions:

with iron;acetic acid in water; for 2 h;Reflux;

Steps:

4 Preparation of 2-acetamido-4-aminopyridine

Iron powder (140g, 2.5mol) will be reducedPut acetic acid (458ml, 8mol) and 100mL water into a 1L four-mouth reaction flask.Heat reflux 15min,Cool to 85°C,Compound c (197 g, 1 mol) was added slowly,The reaction is exothermic,After the addition of heat reflux 2h,The reaction is completeCool to room temperatureSuction filtrationFilter residue washed,Combine the filtrate,Add 2g of powder to the filtrate,To prevent the product from being oxidized,Before proceeding with the next reaction,Rotary evaporation of the solution gave solid compound d (139.2 g, 92.2%).

References:

CN107759515,2018,A Location in patent:Paragraph 0035-0037