ChemicalBook CAS DataBase List 2,6-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE

2,6-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE synthesis

5synthesis methods

Product Name:2,6-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE
CAS Number:883549-54-0
Molecular formula:C12H11NO3
Molecular Weight:217.22

67-56-1 Synthesis

67-56-1
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2-CHLORO-6-METHOXYQUINOLINE-3-CARBALDEHYDE

73568-29-3
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$15.00/1g

883549-54-0
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$110.00/50mg

Yield:883549-54-0 78%

Reaction Conditions:

with potassium hydroxide at 60;

Steps:

1.1 General procedure for the synthesis of 2-methoxyquinoline-3-carbaldehydes (19-24)

General procedure: To a solution of KOH (75.7 mmol) in MeOH (100 mL) was added the corresponding 2-chloro-3-quinolinecarbaldehyde (52.2 mmol) with constant stirring. The mixture was heated under reflux for 2.5-6 h and then cooled to room temperature. The product was precipitated out by adding water (300 mL) and then collected by vacuum filtration. The dried crude was recrystalised in DCM to afford compounds in yields ranging from 42-89%.

References:

Bokosi, Fostino R.B.;Beteck, Richard M.;Mbaba, Mziyanda;Mtshare, Thanduxolo E.;Laming, Dustin;Hoppe, Heinrich C.;Khanye, Setshaba D. [Bioorganic and Medicinal Chemistry Letters,2021,vol. 38] Location in patent:supporting information

104-94-9 Synthesis