ChemicalBook CAS DataBase List 2,6-Difluorobenzoic acid

2,6-Difluorobenzoic acid synthesis

13synthesis methods

Product Name:2,6-Difluorobenzoic acid
CAS Number:385-00-2
Molecular formula:C7H4F2O2
Molecular Weight:158.1

1897-52-5 Synthesis

1897-52-5
530 suppliers
$7.00/10g

385-00-2
419 suppliers
$5.00/5g

Yield:385-00-2 85%

Reaction Conditions:

with water;sodium hydroxide at 150; under 1875.19 Torr; for 10 h;Autoclave;

Steps:

Add 139 g to the autoclave2,6-difluorobenzonitrile,120 g of sodium hydroxide and 180 g of water(The molar ratio of the three is 1: 3: 10), heated to 150 ° C, reacted for 10 hours, and the controlled pressure was 0.25 MPa.After completion of the reaction, the reaction solution was poured into a beaker,Adjust the pH value with 10% sulfuric acid aqueous solutionTo 1, precipitate slightly yellowish solid. By filtration, take solid phase with cold water washing, drying, and then 300mlEthanol and water volume ratio of 2: 1 mixed solution to recrystallize white crystal 6 - fluorosalic acid 168.2g.The yield of 6-fluorosalicylic acid was 85%.The purity of 6-fluorosalicylic acid was 98.5%.

References:

Yangzhou Tianchen Fine Chemical Co., Ltd;Chen, Guoyun;Wang, Chen;Pan, Mingsheng;Chen, Zhongcheng;Miao, Youchang;Liu, Runxing;Cai, Lei;Zhang, Xiaofeng;Luo, Rui CN106336352, 2017, A Location in patent:Paragraph 0013; 0014; 0015

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