ChemicalBook CAS DataBase List 2,6-Dibromo-4-nitroaniline

2,6-Dibromo-4-nitroaniline synthesis

8synthesis methods

Product Name:2,6-Dibromo-4-nitroaniline
CAS Number:827-94-1
Molecular formula:C6H4Br2N2O2
Molecular Weight:295.92

2,6-Dibromo-4-nitroaniline can be used as an intermediate for dyes and organic pigments in chemical production processes. It was prepared from 4-nitroaniline with bromine in tetrachloromethane stirred at 20 ℃ for 1 h.

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Yield:827-94-1 98.7%

Reaction Conditions:

with hydrogenchloride;brominating reagent in dichloromethane;water at 28; for 0.75 - 1 h;

Steps:

5 EXAMPLE 5
To 5.0 ml of dichloromethane containing 4-nitroaniline (1 g, 7.246 m mole) in a 250 ml round bottom flask, 1.45 ml of 12 N hydrochloric acid and 10 ml of deionised water were added. To this reaction mixture, brominating reagent containing (2.9 g) of brominating reagent dissolved in 20 ml of deionised water was added slowly under continuous stirring at 28° C. for a period of 30 to 45 minutes. After completion of the addition, stirring was continued for another 15 minutes. The organic layer was separated and extracted with dichloromethane. The organic layer and the organic extracts were mixed and then washed successively with sodium thiosulphate solution and brine. The product, 2,6-dibromo-4-nitroaniline was dried over anhydrous sodium sulphate and concentrated to yield 98.7%. It was characterized by melting point; NMR; IR and elemental analysis. _

References:

COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH US2004/242939, 2004, A1 Location in patent:Page 4

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100-01-6
10 suppliers
$11.19/25G

827-94-1
238 suppliers
$8.00/25g