2,6-dibromo-4-fluorobenzoic acid synthesis
1synthesis methods
- Product Name:2,6-dibromo-4-fluorobenzoic acid
- CAS Number:91590-90-8
- Molecular formula:C7H3Br2FO2
- Molecular Weight:297.9
Yield:1006-41-3 49%
Reaction Conditions:
Stage #1: with [bis(acetoxy)iodo]benzene;iodine in 1,2-dichloro-ethane at 20; for 1 h;
Stage #2: 4-Fluorobenzoic acidwith palladium diacetate;tetramethylammonium bromide in 1,2-dichloro-ethane at 100; for 24 h;
References:
Mei, Tian-Sheng;Giri, Ramesh;Maugel, Nathan;Yu, Jin-Quan [Angewandte Chemie - International Edition,2008,vol. 47,# 28,p. 5215 - 5219] Location in patent:supporting information; experimental part