ChemicalBook CAS DataBase List 2,4-Dihydroxythieno[2,3-d]pyrimidine

2,4-Dihydroxythieno[2,3-d]pyrimidine synthesis

10synthesis methods

Product Name:2,4-Dihydroxythieno[2,3-d]pyrimidine
CAS Number:18740-38-0
Molecular formula:C6H4N2O2S
Molecular Weight:168.17

4651-82-5 Synthesis

4651-82-5
183 suppliers
$7.00/1g

124-38-9
127 suppliers
$175.00/23402

18740-38-0
90 suppliers
$20.00/250mg

Yield: 94%

Reaction Conditions:

with 1,5-diazabicyclo[4.3.0]non-5-ene 2,2,2-trifluoroethanol at 90; for 48 h;

Steps:

8 Example 8 Synthesis of Compound 2h
Compound 1h (1 mmol, 124 mg), [HDBN+][TFE-] (6 mmol, 1.35 g) was added to a 10 ml round bottom flask. In a CO2 environment, the reaction was heated to 90°C for 48 hours, the reaction was stopped, the temperature was cooled to room temperature, and a saturated aqueous solution of NH4Cl was added. Adjust the pH to neutral, extract three times with 20ml CH2Cl2, collect the CH2Cl2 solution and dry it over anhydrous sodium sulfate. After filtration, the solution was removed by evaporation under reduced pressure, and the resulting solid was separated by silica gel column chromatography (eluent: CH2Cl2:CH3OH=15:1).158 mg of a pale yellow solid compound for 2 h, yield 94%.

References:

Guizhou Medical University;Li Chun;Zhang Lin;Yang Yuanyong CN107698587, 2018, A Location in patent:Paragraph 0051; 0052; 0053