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115382-33-7

2,4-Dichloro-3-Methoxybenzoic acid synthesis

9synthesis methods
-

Yield:115382-33-7 85%

Reaction Conditions:

Stage #1: 2,6-dichloroanisolewith sec.-butyllithium in tetrahydrofuran;cyclohexane at -75; for 0.75 h;
Stage #2: carbon dioxide in tetrahydrofuran;cyclohexane at 25;

References:

Schlosser, Manfred;Heiss, Christophe;Marzi, Elena;Scopelliti, Rosario [European Journal of Organic Chemistry,2006,# 19,p. 4398 - 4404]