2-(4-BROMO-PHENYL)-N-HYDROXY-ACETAMIDINE synthesis
- Product Name:2-(4-BROMO-PHENYL)-N-HYDROXY-ACETAMIDINE
- CAS Number:422560-40-5
- Molecular formula:C8H9BrN2O
- Molecular Weight:229.07
16532-79-9
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5470-11-1
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422560-40-5
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$36.50/250mg
Yield:-
Reaction Conditions:
with sodium carbonate in methanol;water;
Steps:
63.B Step B
Step B 2-(4-bromophenyl)-1-(hydroxyimino)ethylamine To a stirring solution of 2-(4-bromophenyl) ethanenitrile in methanol/water (1 eq/1 eq, 0.1 M) was added hydroxyamine hydrochloride (2.1 eq) and sodium carbonate (2.0 eq). The reaction was stirred at 60° C. for 5 hrs. The reaction was diluted with ethyl acetate and separated. The organic layer was washed with 10% hydochloric acid and separated. The aqueous layer was neutrized with 10% sodium carbonate and extracted with ethyl acetate. The organic layer was dried with magnesium sulfate, filtered and concentrated in vacuo to afford the product. EI-MS m/z 229, 231(M+H)+
References:
US6514964,2003,B1