2-(4-BROMO-BENZYL)-MALONIC ACID synthesis

4synthesis methods

Product Name:2-(4-BROMO-BENZYL)-MALONIC ACID
CAS Number:92013-18-8
Molecular formula:C10H9BrO4
Molecular Weight:273.08

70146-78-0 Synthesis

2-(4-BROMO-BENZYL)-MALONIC ACID DIETHYL ESTER

70146-78-0
34 suppliers
$28.00/100mg

92013-18-8
21 suppliers
$147.00/500mg

Yield:92013-18-8 100%

Reaction Conditions:

with water;potassium hydroxide in ethanol at 20; for 14 h;

Steps:

95 Compound 95g. 2-(4-bromobenzyl)malonic acid

To a solution of Compound 95f (500 mg, 1.52 mmol) in a mixture of EtOH (2.5 ml) and water (1.25 mL) was added KOH (298 mg, 5.32 mmol) and the reaction mixture wasstirred at RT for 14h. The reaction mixture was acidified with 3N HC1 and the product wasextracted with Et20 (3X). The organic phases were combined and the composite was driedover MgSO4 and concentrated under reduced pressure to give Compound 395g (420 mg, 100% yield) as a white solid. MS m/z 272.9 (M+H). 1HNMR (CHLOROFORM-d) 6: 7.42-7.47 (m, 2H), 7.07-7.16 (m, 2H), 3.76 (t, J=7.4 I-Iz, 1H), 3.28 (d, J=7.4 Hz, 2H).

References:

WO2017/96130,2017,A1 Location in patent:Page/Page column 116; 119