ChemicalBook CAS DataBase List 2-(4'-BROMO-2'-FLUOROPHENOXY)PROPANE

2-(4'-BROMO-2'-FLUOROPHENOXY)PROPANE synthesis

3synthesis methods

Product Name:2-(4'-BROMO-2'-FLUOROPHENOXY)PROPANE
CAS Number:202865-80-3
Molecular formula:C9H10BrFO
Molecular Weight:233.08

2105-94-4 Synthesis

2105-94-4
353 suppliers
$6.00/5g

67-63-0 Synthesis

67-63-0
1590 suppliers
$16.00/25ML

202865-80-3
72 suppliers
$32.00/1g

Yield: 99%

Reaction Conditions:

with di-isopropyl azodicarboxylate;triphenylphosphine in tetrahydrofuran at 45; for 1 h;Reflux;

Steps:

20.1
Step 1: 4-bromo-2-fluoro-1-isopropoxybenzene To a solution of 4-bromo-3-fluorophenol (10 g, 52.35 mmol) in THF (100 ml), isopropyl alcohol (4.8 ml, 62.62 mmol) and triphenylphosphine (20.6 g, 78.52 mmol) were added and heated to 45'C followed by diisopropylazodicarboxylate (15.4 ml, 78.52 mmol). The mixture was refluxed for 1 h, concentrated and the residue was purified by column chromatography with ethyl acetate:petroleum ether to afford the title compound as a colourless liquid (13.1 g, 99%) which was used without purification in the next step.

References:

Rhizen Pharmaceuticals SA;Incozen Therapeutics Pvt. Ltd. US2011/281865, 2011, A1 Location in patent:Page/Page column 86

121219-03-2 Synthesis