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ChemicalBook CAS DataBase List 2,4,8-TRICHLOROQUINAZOLINE
62484-29-1

2,4,8-TRICHLOROQUINAZOLINE synthesis

5synthesis methods
32315-10-9 Synthesis
Triphosgene

32315-10-9
414 suppliers
$10.00/1g

53312-77-9 Synthesis
2-AMINO-3-CHLOROBENZONITRILE

53312-77-9
156 suppliers
$7.00/100mg

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Yield:62484-29-1 89.6%

Reaction Conditions:

Stage #1: bis(trichloromethyl) carbonatewith triethylamine;Triphenylphosphine oxide in chlorobenzene at 20; for 0.5 h;Cooling with ice;
Stage #2: 2-amino-3-chlorobenzonitrile in chlorobenzene at 120; for 8 h;

References:

Li, Zhenhua;Wu, Danli;Zhong, Weihui [Heterocycles,2012,vol. 85,# 6,p. 1417 - 1426] Location in patent:experimental part

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