ChemicalBook CAS DataBase List 2,4,7-TRIMETHYL-1-INDANONE

2,4,7-TRIMETHYL-1-INDANONE synthesis

10synthesis methods

Product Name:2,4,7-TRIMETHYL-1-INDANONE
CAS Number:89044-50-8
Molecular formula:C12H14O
Molecular Weight:174.24

1-Propanone, 2-bromo-1-(2,5-dimethylphenyl)-2-methyl-

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Yield:89044-50-8 56%

Reaction Conditions:

with aluminum (III) chloride in carbon disulfide; for 1 h;Reflux;

Steps:

1.3 synthesis of 2, 4, 7-trimethyl-1-indanone

with a mechanical stirring, to the reflux condenser of 1 liter to three-opening bottle 132 g (0.44mol) no water AlCl ₃ powder and 600 ml carbon bisulfide, mixing, heating to reflux, through the dropping funnel to the three port slowly adding in the bottle 110.9 g α-bromo -2,5-dimethyl- phenyl isopropyl ketone, continue to reflux 1 hour. After cooling to room temperature the reaction mixture is poured in ice/hydrochloric acid mixture. Separating the organic phase, gas through the gas flow remove carbon disulfide. The remaining liquid extraction with ethyl ether, water-free Na ₂ SO ₄ drying, to 43.1 g 2, 4, 7-trimethyl-1-indanone, yield 56%.

References:

CN103641863,2016,B Location in patent:Paragraph 0047

79-41-4 Synthesis