ChemicalBook CAS DataBase List 2,4,6-trichloro-pyrido[2,3-d]pyrimidine

2,4,6-trichloro-pyrido[2,3-d]pyrimidine synthesis

6synthesis methods

Product Name:2,4,6-trichloro-pyrido[2,3-d]pyrimidine
CAS Number:958360-30-0
Molecular formula:C7H2Cl3N3
Molecular Weight:234.47

Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-chloro-

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958360-30-0
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Yield:958360-30-0 88%

Reaction Conditions:

with P,P-dichlorophenylphosphine oxide at 180; for 6 h;

Steps:

42.b Synthesis of 2,4,6-trichloropyrido[2,3-d]pyrimidine

The mixture of 6-chloropyrido[2,3-d]pyrimidin-2,4(1H,3H)-dione (163.0 mg, 0.82 mmol) and BPOD (2.0 mL) was stirred at 180° C. for 6 hours and then cooled to room temperature. The reaction mixture was poured into water, and it was neutralized with saturated NaHCO₃aqueous solution (pH=7) and then extracted with EtOAc (30.0 mL). The organic layer was washed with brine, dried over anhydrous Na₂SO₄, filtered and then distilled under reduced pressure to obtain white solid compound of 2,4,6-trichloropyrido[2,3-d]pyrimidine (169.0 mg, 88%). [0694] ¹H-NMR (300 MHz, DMSO-d₆); δ: 8.97 (d, 1H, J=2.8 Hz), 8.49 (d, 1H, J=2.8 Hz)

References:

US2014/315888,2014,A1 Location in patent:Paragraph 0693-0694