2,3-DIFLUOROPHENYL ISOTHIOCYANATE synthesis
- Product Name:2,3-DIFLUOROPHENYL ISOTHIOCYANATE
- CAS Number:363179-57-1
- Molecular formula:C7H3F2NS
- Molecular Weight:171.17
463-71-8
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$32.00/10g
4519-40-8
298 suppliers
$10.00/1g
363179-57-1
35 suppliers
$45.00/100mg
Yield:363179-57-1 68%
Reaction Conditions:
with triethylamine in toluene;
Steps:
18.a a
a 2,3-Difluorophenylisothiocyanate Into a solution of 2,3-difluoroaniline (1.0 g, 7.74 mmol) in 30 mL of toluene at room temperature, thiophosgene (0.91 mL, 11.6 mmol) and triethylamine (1.3 mL, 11.6 mmol) was added. The mixture was stirred at room temperature for 16 hours. The mixture was partitioned between ethyl acetate and water. The combined organic layer was then concentrated to give the desired product (910 mg, 68%). 1H NMR (CDCl3) δ 6.98 (m, 2H), 7.11 (m, 1H).
References:
US2003/216375,2003,A1
4519-40-8
298 suppliers
$10.00/1g
363179-57-1
35 suppliers
$45.00/100mg
4519-40-8
298 suppliers
$10.00/1g
16420-13-6
286 suppliers
$5.00/5g
363179-57-1
35 suppliers
$45.00/100mg