2-(3,4-Dihydroquinolin-1(2H)-yl)ethanol synthesis

9synthesis methods

Product Name:2-(3,4-Dihydroquinolin-1(2H)-yl)ethanol
CAS Number:52704-48-0
Molecular formula:C11H15NO
Molecular Weight:177.24

635-46-1 Synthesis

635-46-1
359 suppliers
$5.00/10g

107-21-1 Synthesis

107-21-1
1334 suppliers
$10.00/25g

5840-01-7 Synthesis

5840-01-7
128 suppliers
$10.00/250mg

52704-48-0
12 suppliers
inquiry

Yield:52704-48-0 45% ，5840-01-7 45%

Reaction Conditions:

with palladium on activated charcoal;zinc(II) oxide in water at 150; for 24 h;Sealed tube;

Steps:

4.1. General procedure

General procedure: 1 mmol of amine, 0.07 mmol of Pd/C, 3 mmol of ZnO, 6 mL of distilled water and 6 mL of ethylene glycol were mixed manually inside a 20 mL Teflon flask. Then it was sealed into a steel autoclave and introduced in a preheated oven at 150 °C for 24 h. The reaction mixture was cooled to room temperature, 25 mL of distilled water were added and the crude was filtered through a 0.2 mm Teflon filter. The reaction mixture was extracted with ethyl acetate3 15 ml and organic layers were combined, dried with Na₂SO₄, filtered and concentrated affording the reaction crude that was cheeked by NMR. Crude reaction was purified by chromatotron (1 mm, silica, from hexane to hexane/AcOEt 1:3) affording pure β-amino alcohols.

References:

Llabres-Campaner, Pedro J.;Ballesteros-Garrido, Rafael;Ballesteros, Rafael;Abarca, Belén [Tetrahedron,2017,vol. 73,# 37,p. 5552 - 5561] Location in patent:supporting information

17133-54-9 Synthesis