ChemicalBook CAS DataBase List 2,2'-BIPYRIMIDINE

2,2'-BIPYRIMIDINE synthesis

4synthesis methods

Product Name:2,2'-BIPYRIMIDINE
CAS Number:34671-83-5
Molecular formula:C8H6N4
Molecular Weight:158.16

2,2'-Bipyrimidine can be used as organic intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process. Nickel bromide, 5-trimethylsilyl-2,2'-bipyridine and zinc powder were added in 2-chloropyrimidine and N-methyl-2-pyrrolidone under a atmosphere of nitrogen at room temperature. The obtained mixture was reacted at 70°C for 2 hours to give 2,2'-bipyrimidine.

1722-12-9 Synthesis

1722-12-9
544 suppliers
$10.00/1g

34671-83-5
202 suppliers
$16.00/100mg

Yield:-

Reaction Conditions:

with zinc;5-trimethylsilyl-2,2'-bipyridine;nickel dibromide in 1-methyl-pyrrolidin-2-one at 20 - 70;Inert atmosphere;

Steps:

21
To a glass reaction container equipped with a cooling apparatus, 15.3 mg of nickel bromide, 19.2 mg of 5-trimethylsilyl-2,2'-bipyridine and 91.6 mg of zinc powder were added in an atmosphere of nitrogen at room temperature. To the obtained mixture, 80.2 mg of 2-chloropyrimidine and 5 mL of N-methyl-2-pyrrolidone were added. The obtained mixture was reacted at 70°C for 2 hours to obtain a reaction mixture containing 2,2'-bipyrimidine. The yield of 2,2'-bipyrimidine was 7.9 mg.

References:

Sumitomo Chemical Company, Limited EP2172470, 2010, A1 Location in patent:Page/Page column 43

FullText

31462-54-1 Synthesis