2-[(2-AMINOETHYL)THIO]ETHAN-1-OL synthesis
- Product Name:2-[(2-AMINOETHYL)THIO]ETHAN-1-OL
- CAS Number:24304-84-5
- Molecular formula:C4H11NOS
- Molecular Weight:121.2
Yield:24304-84-5 99.5%
Reaction Conditions:
with sodium hydroxide in water at 50; for 1.5 h;Reagent/catalyst;Solvent;
Steps:
1 Example 1
Step 1. In a 500 ml four-necked flask equipped with magnetic stirring, 20.0 g of β-mercaptoethanol and 1.0 g of Fe-EG catalyst were added, and 50 ml of a newly prepared 30% strength NaOH solution was added dropwise at room temperature.After 15 minutes of dropwise addition, the temperature was raised to 50 ° C, and 30.0 g of 2-chloroethylamine hydrochloride was dissolved in 17.3 ml of water.Slowly drip into the above reaction bottle, 1h drop addition, continue to keep warm at 50 ° C and stir for 0.5h;Step 2, after the reaction, the solution is light yellow transparent, a small amount of white solid precipitates at the bottom, the system pH=10, the upper clear liquid is dried at 50 ° C to obtain a beige viscous liquid, the product is dissolved with absolute ethanol, filtered, and the filtrate is decompressed. Distillation gave the pale yellow viscous liquid product 2-amino-2-hydroxy-diethyl sulfide.
References:
CN108373432,2018,A Location in patent:Paragraph 0008; 0009; 0010; 0011; 0012; 0013; 0014-0029
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