ChemicalBook CAS DataBase List 1H-Pyrrolo[2,3-c]pyridine-5-carboxylicacid(9CI)

1H-Pyrrolo[2,3-c]pyridine-5-carboxylicacid(9CI) synthesis

5synthesis methods

Product Name:1H-Pyrrolo[2,3-c]pyridine-5-carboxylicacid(9CI)
CAS Number:130473-27-7
Molecular formula:C8H6N2O2
Molecular Weight:162.15

108-47-4
216 suppliers
$9.00/1g

1H-Pyrrolo[2,3-c]pyridine-5-carboxylicacid(9CI)

130473-27-7
55 suppliers
$80.00/100mg

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: H₂SO₄; KNO₃ / 12 h / 0 - 130 °C
1.2: 2.5 g / benzeneselenic anhydride / dioxane / 10 h / Heating
2.1: 90 percent / p-toluenesulfonic acid / toluene / 2 h / Heating
3.1: 69 percent / dimethylformamide / 3 h / 90 °C
4.1: p-toluenesulfonic acid / acetonitrile; H₂O / 5 h / Heating
5.1: HCO₂H; aq. H₂O₂ / 0 - 5 °C

References:

Wishka, Donn G.;Walker, Daniel P.;Yates, Karen M.;Reitz, Steven C.;Jia, Shaojuan;Myers, Jason K.;Olson, Kirk L.;Jacobsen, E. Jon;Wolfe, Mark L.;Groppi, Vincent E.;Hanchar, Alexander J.;Thornburgh, Bruce A.;Cortes-Burgos, Luz A.;Wong, Erik H. F.;Staton, Brian A.;Raub, Thomas J.;Higdon, Nicole R.;Wall, Theron M.;Hurst, Raymond S.;Walters, Rodney R.;Hoffmann, William E.;Hajos, Mihaly;Franklin, Stanley;Carey, Galen;Gold, Lisa H.;Cook, Karen K.;Sands, Steven B.;Zhao, Sabrina X.;Soglia, John R.;Kalgutkar, Amit S.;Arneric, Stephen P.;Rogers, Bruce N. [Journal of Medicinal Chemistry,2006,vol. 49,# 14,p. 4425 - 4436]