Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate L-(+)-tartarate synthesis
2synthesis methods
- Product Name:Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate L-(+)-tartarate
- CAS Number:131278-84-7
- Molecular formula:C13H23NO8
- Molecular Weight:321.3236
Yield:-
Steps:
Multi-step reaction with 6 steps
1.1: acetic acid; sodium hypochlorite / water / 2 h / 0 - 10 °C
1.2: 0 - 20 °C
2.1: hydrogenchloride / water; dichloromethane / 1.5 h / 0 - 10 °C
3.1: water; dichloromethane / 0 - 20 °C
4.1: hydrogenchloride / water / 20 - 60 °C
5.1: thionyl chloride / 0 °C / Reflux
6.1: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate
References:
US2014/88310,2014,A1
