ChemicalBook CAS DataBase List 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole synthesis

8synthesis methods

Product Name:5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole
CAS Number:120068-79-3
Molecular formula:C11H5Cl2F3N4
Molecular Weight:321.09

Butanedinitrile, 2-[2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazinylidene]-

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5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

120068-79-3
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$10.00/1g

Yield:120068-79-3 97%

Reaction Conditions:

with ammonia in ethanol;water at 0; for 0.166667 h;

Steps:

ii REFERENCE EXAMPLE ii)
Preparation of 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

REFERENCE EXAMPLE ii) Preparation of 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole ammonia (20 microlitres of an 8% ammonia solution in water) was added to a mixture of the above 2-(2,6-dichloro-4-trifluoromethylphenylhydrazono)-succinonitrile (0.077 g) in ethanol (1 ml) and water (0.2 ml) at 0° C. After 10 minutes the mixture was extracted (dichloromethane) and evaporated to give 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (0.076 g, 97% yield) Purity 98% (by hplc).

References:

US6392081,2002,B1 Location in patent:Page column 9

40497-11-8 Synthesis