Yield:-

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine at 90 - 115; for 6 h;Product distribution / selectivity;

Steps:

7.1

A mixture containing (R)-(4-chlorophenyl)phenyl methylamine free base (4.34 g, 20 mmol, optical purity 99%), N,N-bis(2-chloroethyl)phenyl carbamate (5.76 g, 22 mmol) and diisopropyl ethylamine (10 ml) was stirred under nitrogen at 90° C. for 1 hour and further at 115° C. for 5 hours.After cooling down, 20 ml ethyl acetate was added. Mixture was stirred for 20 min, solid was filtered off and washed with ethyl acetate (2×25 ml). Filtrate and washings were combined, washed with H₂O (2×25 ml), and concentrated to give an oily material (8.9 g).

References:

US2009/143582,2009,A1 Location in patent:Page/Page column 6