ChemicalBook CAS DataBase List 11-METHYLBENZ[A]ANTHRACENE

11-METHYLBENZ[A]ANTHRACENE synthesis

14synthesis methods

Product Name:11-METHYLBENZ[A]ANTHRACENE
CAS Number:6111-78-0
Molecular formula:C19H14
Molecular Weight:242.31

612-55-5
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$48.00/500mg

1123-56-4
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$16.00/5g

6111-78-0
11 suppliers
$165.00/10mg

Yield: 41%

Reaction Conditions:

with trifluorormethanesulfonic acid;palladium diacetate;silver trifluoroacetate;acetic acid;glycine at 100; for 24 h;Sealed tube;

Steps:

General Procedure for the Synthesis of Polycyclic Aromatic Hydrocarbons
General procedure: A sealed tube with magnetic stir bar was charged with substrate 1 (0.24 mmol), glycine (0.1 mmol, 7.5 mg), Pd(OAc)₂ (0.02 mmol, 4.45 mg), AgTFA (0.24 mmol, 53.01 mg) and 2 (0.2 mmol) under air. After addition of AcOH (2 mL) as solvent, TfOH (0.1 mmol, 15.0 mg) was added. The reaction mixture was allowed to stir at 100 °C for 24 hours. Upon completion, the reaction mixture was cooled to room temperature, diluted with DCM, and then extracted with saturated NaHCO₃ aqueous solution. The organic layer was dried over anhydrous Na₂SO₄ and concentrated in vacuo. The crude residue was purified by column chromatography on silica gel using PE as the eluent to afford the desired products.

References:

Wang, Ziqi;Dong, Wendan;Sun, Bing;Yu, Qinqin;Zhang, Fang-Lin [Tetrahedron,2019,vol. 75,# 30,p. 4031 - 4041] Location in patent:supporting information