4-Chloro-2-methoxy-5-nitro-benzoic acid methyl ester synthesis

4synthesis methods

Product Name:4-Chloro-2-methoxy-5-nitro-benzoic acid methyl ester
CAS Number:109069-75-2
Molecular formula:C9H8ClNO5
Molecular Weight:245.62

68255-77-6
14 suppliers
$90.00/500mg

4-Chloro-2-methoxy-5-nitro-benzoic acid methyl ester

109069-75-2
20 suppliers
$45.00/100mg

Yield:-

Reaction Conditions:

with sodium chloride;sulfuric acid in methanol;

Steps:

P.103 Methyl 4-mercapto-5-nitro-o-anisate

Production Example 103 Methyl 4-mercapto-5-nitro-o-anisate To a solution of 3.1 g of 4-chloro-5-nitro-o-anisic acid in methanol (100 ml) was added a catalytic amount of sulfuric acid and the resulting mixture was heated under reflux for 3 hours. Then the reaction mixture was poured into ice/water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, 3.3 g of methyl 4-chloro-5-nitro-o-anisate was obtained as pale yellow crystals.

References:

US6518423,2003,B1

67-56-1 Synthesis