成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

102029-58-3

3-O-ACETYL-6-O -BENZOYL-5-O-(METHYLSULFONYL)-1,2-O-ISOPROPYLIDENE-ALPHA-D-GLUCOFURANOSE synthesis

3synthesis methods
-

Yield:102029-58-3 90.6%

Reaction Conditions:

Stage #1: 3-O-acetyl-1,2-O-isopropylidene-α-D-glucofuranose;benzoyl chloridewith pyridine in tetrahydrofuran at 0 - 20; for 4 h;
Stage #2: methanesulfonyl chloridewith triethylamine in tetrahydrofuran at 0 - 20; for 2.5 h;

Steps:

3.c

c. Dissolve the substance obtained in step b (compound 4) in anhydrous tetrahydrofuran (1.2L) and add anhydrous pyridine (1.5mol),The solution was cooled to 0 with ice water and then benzoyl chloride BzCl (1.2mol) was added dropwise,After the dropwise addition is completed, react for 4h at room temperature. After the reaction is completed, continue to add triethylamine (2.5mol),After cooling to 0°C, methanesulfonyl chloride MsCl (92.89mL, 1.2mol) was added dropwise to the reaction solution. After the addition, the reaction was stirred at room temperature for 2.5h.After the reaction is completed, the reaction solution is slowly poured into a saturated sodium bicarbonate solution at 0°C,Separate the liquids and extract with dichloromethane. The extract phase is washed with water, 1.5mol/L hydrochloric acid aqueous solution, water, saturated brine, and then dried with anhydrous sodium sulfate.Filtration, concentration, and column chromatography under reduced pressure (eluent: petroleum ether: ethyl acetate = 7:1 (volume ratio)) to obtain 402.2 g of a white solid product (yield: 90.6%).

References:

CN113416220,2021,A Location in patent:Paragraph 0074-0076; 0079

3-O-ACETYL-6-O -BENZOYL-5-O-(METHYLSULFONYL)-1,2-O-ISOPROPYLIDENE-ALPHA-D-GLUCOFURANOSE Related Search: